What Families Should Know About Nitrous Oxide Abuse. Nitrous oxide abuse can be hard to spot — but the signs are often right in front of you. Families might notice empty whippet canisters or balloons in the trash, unexplained spending, or changes in walking, balance, and speech. Other red flags include tingling or numbness in hands and feet, paranoia, isolation, and secretive behavior. These symptoms can signal neurological damage and deepening psychological dependence. Knowing the signs could s