The Human Heart Contains Distinct Macrophage Subsets with …
Macrophages within the mouse heart are partitioned into CCR2- and CCR2+ subsets with divergent origins, repopulation mechanisms, and functions. Here we demonstrate that the human myocardium also contains distinct subsets of CCR2- and CCR2+ macrophages.
A Network of Macrophages Supports Mitochondrial Homeostasis in the Heart
Cardiac macrophages were isolated from hearts of DsRed transgenic mice by FACS sorting using an Aria Cell Sorter (BD) equipped with DIVA software (BD). We co-cultured these DsRed+ macrophages with HL1 GFP cells for 18 hours in an 8-well IBIDI plate and performed imaging for 2 hours in a Nikon Time Lapse microscope at 37°C and 5% CO 2 .
The human heart contains distinct macrophage subsets with …
Jun 11, 2018 · Macrophages within the mouse heart are partitioned into CCR2− and CCR2+ subsets with divergent origins, repopulation mechanisms, and functions.
Macrophages, Metabolism and Heterophagy in the Heart
Feb 3, 2022 · At the tissue level, macrophages control metabolism of other cells either directly, through production of cytokines and miRs, or indirectly, by regulating metabolite availability through recycling, production, degradation, and competition.
Cardiac macrophage metabolism in health and disease
Mar 1, 2024 · In this review, we detail the unique functional roles and metabolic profiles of tissue-resident and monocyte-derived cardiac macrophages during embryonic development and adult tissue homeostasis and in response to pathologic and physiologic stressors.
Macrophages and Cardiovascular Health - PubMed
Oct 1, 2018 · In this review, we will highlight signals that regulate macrophage supply and function, imaging applications that can detect changes in cell numbers and phenotype, and opportunities to modulate cardiovascular inflammation by targeting macrophage biology.
Cardiac macrophage subsets differentially regulate lymphatic …
Aug 19, 2021 · We observed that the expression of LYVE-1, a receptor for hyaluronic acid, identified two main cardiac macrophage subpopulations in mouse heart. The subpopulation of macrophages positive for...
Monocyte and Macrophage Heterogeneity in the Heart
Jun 7, 2013 · Monocytes and macrophages are innate immune cells that reside and accumulate in the healthy and injured heart. The cells and their subsets pursue distinct functions in steady-state and disease, and...
Novel functions of macrophages in the heart: insights into …
Apr 3, 2019 · Cardiac macrophages from SAUNA-treated mice were predominantly MHC II high and produced more IL-10 than macrophages from healthy hearts. Monocyte- and macrophage-specific deletion of IL-10 using CX3CR1-Cre and IL-10-floxed mice resulted in improved diastolic function after SAUNA treatment.
Cells of the adult human heart - Nature
Sep 24, 2020 · In the immune compartment, we identify cardiac-resident macrophages with inflammatory and protective transcriptional signatures.