Neutrophils as regulators of cardiovascular inflammation
Jan 29, 2020 · In the context of cardiovascular complications of atherosclerosis, we highlight the dichotomous role of neutrophils in pathogenic and repair processes in stroke, heart failure, myocardial ...
Role of Neutrophils in Ischemic Heart Failure - PMC
Intensified neutrophilic leukocytosis (neutrophilia) and sustained activation of neutrophils is the predominant factor that determines over activated inflammation in acute HF and the outcome of long-term chronic HF.
Role of Neutrophils in Cardiac Injury and Repair Following …
The circulating neutrophil count positively correlates to infarct size, death, and heart failure development [19,20]. Experimental studies have also revealed that either neutrophil depletion or inhibition reduces cardiac injury and infarct size [ 21 , 22 , 23 , 24 ].
Neutrophils are indispensable for adverse cardiac remodeling in heart ...
Persistent immune activation contributes significantly to left ventricular (LV) dysfunction and adverse remodeling in heart failure (HF). In contrast to their well-known essential role in acute myocardial infarction (MI) as first responders that clear …
Role of neutrophils in ischemic heart failure - ScienceDirect
Jan 1, 2020 · Timely and optimal activation of neutrophils is essential for resolution of inflammation and cardiac tissue repair. Not only over-activation but also under-activation contribute to pathological remodeling and heart failure. Neutrophils are emerged as a surrogate marker of cardiovascular risk.
KLF2 regulates neutrophil activation and thrombosis in cardiac ...
Feb 1, 2022 · Using a mouse model of angiotensin II–induced nonischemic cardiac dysfunction, we showed that neutrophils played an essential role in the pathogenesis and progression of heart failure. Mechanistically, chronic angiotensin II infusion activated a neutrophil KLF2/NETosis pathway that triggered sporadic thrombosis in small myocardial vessels ...
Neutrophilia Predicts Death and Heart Failure After Myocardial ...
Sep 1, 2009 · We examined the associations of neutrophil count with mortality and post-MI heart failure (HF) and their incremental value for risk discrimination in the community. Methods and Results— MI was diagnosed with cardiac pain, biomarkers, and Minnesota coding of the ECG.
Neutrophil to lymphocyte ratio (NLR) prognostic effects on heart ...
Neutrophil to lymphocyte ratio (NLR), as a recent inflammatory index, has been reported to be a prognostic tool in different diseases. However, implication of this ratio in heart failure (HF) is less investigated. In this systematic review and ...
Neutrophil Extracellular Traps in Myocardial Tissue Drive Cardiac ...
Jun 7, 2024 · Our findings suggest that NETs in the myocardium contribute to cardiac dysfunction and are associated with adverse outcomes in patients with dilated cardiomyopathy, potentially through mitochondrial dysfunction of cardiomyocytes.
Nov 27, 2023 · Neutrophils are the irst leukocytes to infiltrate the heart in response to acute MI and are essential for proper wound healing, providing phagocytic clearance of dead cells and facil-itating reparative macrophage polarization and subsequent resolution of inflammation [10,11].