All News - ALZFORUM
6 days ago — ALZFORUM is a website that covers the latest news and research on Alzheimer's disease and related dementias. Browse the most recent articles on topics such as biomarkers, genetics, pathology, models, and more.
A New Era of Alzheimer’s Treatment - ALZFORUM
Other stakeholders hailed the decision, as well. In addition to positive reaction from advocacy groups such as the Alzheimer’s Association and Us Against Alzheimer’s, the Global Alzheimer’s Platform commended the FDA for its stance, and the National Institutes of Health called the approval a milestone achievement. “The hope is greater ...
ALZFORUM | NETWORKING FOR A CURE
4 days ago — ALZFORUM is a website for researchers, clinicians, and advocates to share and discuss the latest news and research on Alzheimer's disease and related dementias. Browse news articles, webinars, grants, jobs, and join the conversation with other members.
Revised Again: Alzheimer's Diagnostic Criteria Get Another …
Sep 16, 2022 — The new criteria, based on amyloid and tau biomarkers, aim to improve accuracy and accessibility of AD diagnosis. They also stage disease based on biomarker change and co-pathologies, and are open to feedback from the field.
2022, a Year in Review - ALZFORUM
Sep 16, 2022 — In 2022, it cleared a Phase 3 trial for agitation in Alzheimer's, hence this troubling symptom of advanced Alzheimer's dementia may soon join its list of approved indications. Biomarkers Markers of both the biofluid and brain imaging kind are essential tools for intervention trials and cohort studies, and 2022 was a good year on this front.
Do Two APOE4 Alleles Always Mean Alzheimer's? - ALZFORUM
May 10, 2024 — They used these numbers to counsel participants in the Alzheimer’s Prevention Initiative’s Generation trial, which specifically enrolled APOE4 carriers (Sep 2016 news). They also noted that at the time of enrollment, a third of APOE4 homozygotes, between the ages of 60 to 75, did not meet the criteria for amyloid positivity.
Finally: Big Win on All Outcomes for Lecanemab in Phase 3 Topline ...
Oct 12, 2022 — Alzheimer’s researchers hailed the news as a major advance. In particular, they welcomed the straightforward findings after the highly contested rollout of aducanumab last year. “What the field needed was a clearly positive result from a trial completed and conducted per protocol,” Gil Rabinovici at the University of California, San ...
Alzheimer’s Gene MS4A4A Governs the State of Microglia
Mar 3, 2023 — It lowered expression of MS4A4A itself. Some of these data were previously presented at the 2021 Alzheimer’s Association International Conference (Aug 2021 conference news). More Greens, Please. In people with the more common GG allele at the rs1582763 locus, few microglia assume the anti-inflammatory interferon profile (green).
Polygenic Scores Point to Microglia, Astrocytes in Alzheimer's ...
Dec 15, 2023 — A study used genetic risk variants to explore the roles of microglia and astrocytes in AD pathology and cognitive decline. Findings suggest that microglia influence Aβ and tau accumulation, while astrocytes affect amyloid deposition early on.
Massive GWAS Meta-Analysis Digs Up Trove of Alzheimer’s Genes
Feb 25, 2021 — Geneticists at the International Genomics of Alzheimer’s Project analyzed more than 35,000 cases to find five new loci (Mar 2019 news). A separate effort went broader by including UK Biobank samples from people with family histories of dementia, known as genome-wide association-by-proxy (GWAX); it uncovered nine new genes among almost 72,000 ...