Cancer Research6d
Non-selective b adrenergic receptor inhibitors impair hematopoietic regeneration in mice and humans after hematopoietic cell transplants
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Cancer Research6d
ADC for Lymphoma Elicits Near-Perfect Response Rate
In a phase II trial, the ROR1-targeting antibody–drug conjugate zilovertamab vedotin led to a complete response in nearly 100% of patients with diffuse large B-cell lymphoma.
Cancer Research6d
Triple Combination of MEK, BET, and CDK Inhibitors Significantly Reduces Human Malignant Peripheral Nerve Sheath Tumors in Mouse Models
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research9d
The Neuron–Tumor Connectome Supports Glioblastoma Progression
Major Finding: Tumor-connected neurons promote glioblastoma growth, invasion, and resistance to radiotherapy. Concept: Rabies virus–based retrograde tracing of neurons reveals their integration with ...
Cancer Research9d
Subcutaneous Nivolumab Earns FDA Nod
Bristol Myers Squibb announced that the FDA approved nivolumab and hyaluronidase (Opdivo Qvantig) for subcutaneous injection across all currently approved solid tumor indications for intravenous (IV) ...
Cancer Research9d
Tislelizumab Approved for New Indication
The anti-PD-1 mAb tislelizumab (Tevimbra; BeiGene) earned FDA approval for gastric and gastroesophageal junction cancers in combination with chemotherapy, following its approval earlier this year for ...
Cancer Research10d
Challenges to innovation arising from current companion diagnostics regulations and suggestions for improvements
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research10d
Modified CARs Self-Condense to Form Optimal Immunological Synapses
Major Finding: Incorporating a modified CD3ε intracellular domain into a chimeric antigen receptor (E-CAR) improves signaling. Concept: E-CARs phase separate and form mature synapses that support ...
Cancer Research10d
Pediatric Cancer Research Funding Rescued by Senate
After the U.S. Congress pulled funding for a few pediatric cancer programs from the bill passed last week to fund the government through March 14, the Senate voted unanimously to restore a $12.6 ...
Cancer Research16d
Encorafenib Granted Accelerated Approval for Colon Cancer
The FDA granted accelerated approval to encorafenib (Braftovi; Array BioPharma/Pfizer), a BRAF inhibitor, in combination with the anti-EGFR mAb cetuximab (Erbitux; Eli Lilly) and the chemotherapy ...
Cancer Research17d
Stratified Medicine Paediatrics: Cell free DNA and serial tumour sequencing identifies subtype specific cancer evolution and epigenetic states
Copyright held by the owner/author(s). This open access article is distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International ...
Cancer Research17d
Novel Degrader Shows Anti–Lymphoma and Myeloma Activity
The cereblon E3 ligase modulator cemsidomide showed activity against multiple myeloma and two types of non–Hodgkin lymphoma in a phase I study.