Using α-syn fibril-induced PD model, researchers aimed to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain by the wireless DBS nanosystem. After stereotactic ...

Using an α-syn fibril-induced PD model, the researchers attempted to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain through use of the wireless DBS nanosystem.

Its pathological hallmark is the abnormal aggregation of α-synuclein (α-syn) into insoluble fibrils and Lewy bodies, leading to the degeneration and death of dopaminergic neurons in the substantia ...

However, it now appears one of the lasting effects of a silent stroke can be the death of dopaminergic neurons in the substantia nigra in the brain, which is an important region for movement ...

This results in ATP and ion homeostasis disturbances, which lead to selective death of the substantia nigra dopaminergic neurons. Well known as a Parkinson's disease model, the MPTP animal model ...

Results suggest that the implanted neurons have survived transplantation ... producing cells in a part of their midbrain called the substantia nigra, which is responsible for motor control.