– 53.7% mean splicing correction observed following a single 15 mg/kg dose of PGN-EDODM1, with all patients showing an improvement in splicing – – PGN-EDODM1 was generally well-tolerated at 15 mg/kg, ...
A new research paper featured as the cover of Volume 17, Issue 12 of Aging-US was published on December 22, 2025, titled “A combination of differential expression and network connectivity analyses ...
Tim is an Australian Senior Editor based in Germany who has been passionate about video games since he first picked up a PlayStation 1 controller to play Crash Bandicoot as a kid. He started out with ...
Boosting levels of a certain molecule that declines with age was found to restore memory and brain function in Alzheimer’s disease (AD) models – not just by improving energy metabolism, as previously ...
Alzheimer's Disease (AD), the leading cause of dementia, affects nearly 40 million individuals globally, resulting in a gradual loss of memory and independence. Despite extensive research over the ...
"I hope when a producer loads this piano sound, they’ll feel connected to the music that inspired it," Legend said. By Ethan Millman Music Editor John Legend is bringing the iconic piano sound from ...
Introduction: Mediator of RNA polymerase II transcription subunit 25 (MED25), a crucial component of the transcriptional coactivator complex, plays a significant role in the transcription of most RNA ...
The final, formatted version of the article will be published soon. Background: Joubert syndrome (JS) is a rare human genetic disorder classified as a canonical ciliopathy, with potential involvement ...
Panelists discuss how splice modifiers work by enhancing protein production from the SMN2 gene, with risdiplam (Evrysdi) being an oral daily medication and nusinersen (Spinraza) being administered ...
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