This study presents a valuable finding on the alterations in the autophagic-lysosomal pathway in a Huntington's disease model. The evidence supporting the claims of the authors is solid. However, the ...

HDYO released data from recent surveys of the global HD community. Learn more about the findings and how surveys can help ...

Densitometry was performed with Image J and the result for each protein of interest was normalized by its corresponding GAPDH blot and presented in the bar graph. Values are the Mean +/- SEM for each ...

neurobiological and refined clinical markers to understand the early progression of Huntington’s disease (HD), prior to the point of traditional diagnosis, in persons with a known gene mutation. Here ...

Huntington’s disease symptoms are linked to expanding DNA repeats (CAG) that become toxic in brain cells over time The "ticking DNA clock" accelerates after 80 repeats, killing neurons within ...

The team found that although functions such as movement, thinking or behavior remained normal for a long time before the onset of symptoms in Huntington's disease, subtle changes to the brain were ...

The team found that although functions such as movement, thinking or behavior remained normal for a long time before the onset of symptoms in Huntington's disease, subtle changes to the brain were ...

CAMBRIDGE, Massachusetts ‒ For decades it's been one of the defining mysteries of Huntington's disease. Why does the terrible devastation of mind and body start earlier in some people who ...

This type of "somatic expansion" occurs in only the specific types of brain cells that later die in Huntington's disease. Only once a cell's DNA expansion reaches a threshold number of CAGs ...

Huntington's disease, a fatal hereditary brain disorder, is linked to a genetic mutation that remains harmless for decades before expanding and producing toxic proteins that kill brain cells.