Further analysis into NRG1 revealed that it binds directly to the HER3 receptor on cancer cells and, together with the HER2 receptor, activates signaling pathways that ensure CTCs growth and survival.

The list includes several groundbreaking therapies that are expected to change the treatment landscape for several diseases and conditions.

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In the latest recitation, Bristol-Myers Squibb is paying $800 million upfront for rights to a HER3-directed ADC from China’s SystImmune in a deal that could swell to $8.4 billion. It gives BMS ...

The HER3-directed ADC will be tested in patients whose disease had progressed despite earlier treatment with EGFR inhibitors, including third-generation drugs like AZ's Tagrisso (osimertinib).

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