"We had previously demonstrated that the p53 gene product--the most commonly mutated gene in human cancer--controls ... using cells from patients with ataxia-telangiectasia [AT], a disease ...

Patients with variant A-T have reduced residual ataxia telangiectasia mutated (ATM) kinase function, manifesting with milder, later presenting disease. The heterogeneous phenotype of variant A-T leads ...

In the summer of 1977, Yosef Shiloh, then a graduate student, visited an Israeli Moroccan Jewish family with several children affected by ataxia-telangiectasia (A-T ... ATM (A-T, mutated). The gene ...

The Schmitt family is grateful for the resources through A-T Children’s Project, as well as the love and care at St. Jude’s, ...

In addition to its function as an activator of type I IFN synthesis and autophagy, STING can also activate the NF-κB pathway in a TBK1-IKKϵ-dependent or TBK1-independent manner that involves DNA ...

Another combinatorial approach targeted the DNA damage checkpoint protein ataxia telangiectasia mutated and Ras3 related (ATR), a major regulator of the G2/M cell cycle checkpoint (61). Detection of ...

Quince Therapeutics (QNCX) “announced that the U.S. Patent and Trademark Office has issued a Notice of Allowance for U.S. Patent Application ...

Quince Therapeutics, Inc. (Nasdaq: QNCX) is a late-stage biotechnology company dedicated to unlocking the power of a patient's own biology for the treatment of rare diseases. For more information on ...

Editor’s note: This is an automatically generated transcript. Please notify [email protected] if there are concerns regarding accuracy of the transcription. Yeah, so the EGFR mutation lung ...