Background: Maternal high-fat diet (HFD) during ... Maternal mice and 10-week-old offspring were weighed and fasted for 10 h before testing. The baseline blood glucose levels were measured prior to ...

Researchers have demonstrated, for the first time in the world using mice, the ability to overcome significant challenges in ...

Researchers are enhancing the best features of AAV capsids and overcoming their limitations to accelerate gene-based therapies.

Potent in vivo gene editing in skeletal muscle of non-human primates by a novel, ultracompact CRISPR system delivered via a single AAV vector.

This is an important study providing convincing evidence that increased blood pressure variability impairs myogenic tone and diminishes baroreceptor reflex. The study also provides evidence that blood ...

In general, it should be an interesting goal for future work to compare the lead candidates from these and other studies side-by-side in genuine or humanized mouse livers in the presence of anti-AAV ...

In this study, the authors evaluated fos-related antigen 2 (Fra-2) transgenic mice as a novel model for systemic sclerosis-associated pulmonary arterial hypertension. Methods Lung sections of Fra-2 ...