Briola and co-authors determined the structure of the human CTF18 clamp loader bound to PCNA to high resolution, analyzed the structure, and tested a new mechanism involving a human-specific Ctf18 ...

The input of the DeepTXsolver is the parameters of the mechanism model, and the output is the corresponding stationary distribution solution of the model. The input to the DeepTXinferrer is the ...

This study uses electrophysiological recordings, causal manipulations of activity, and modeling to investigate how the maintenance of a spatial location in working memory affects the representation of ...

This fundamental study substantially advances our understanding of the role of zinc in metabolism, specifically a newly established clinical link between mutations in the zinc transporter SLC39A5, ...

This important study describes a first-in-human trial of autologous p63+ stem cells in patients with idiopathic pulmonary fibrosis, a lethal condition for which effective treatments are lacking. The ...

This important study will allow for a better understanding of anthelmintic drug resistance in nematodes, a growing concern for public health. The authors provide a detailed analysis of the role of UBR ...

This valuable study combines experiments and theory to investigate the putative role of spontaneous correlated activity in establishing aligned topographic maps of neural activity in higher-order ...

When exposed to prolonged stressful stimulation, rats start to emit long, frequency-unmodulated 44-kHz ultrasonic vocalizations, usually within the 35–50 kHz range, along with, previously described, ...

Marcks and Marcks-like 1 proteins are required for normal neurite formation and proliferation of neuro-glial progenitors during development and regeneration of the Xenopus spinal cord implicating ...

Studying the fecal microbiota of wild baboons helps provide new insight into the factors that influence biological aging.

Combining intermittent fasting with localised Wnt3a treatments can rejuvenate bone repair in older mice, offering hope for reversing age-related tissue decline.

Endometriosis is a debilitating disease affecting 190 million women worldwide and the greatest single contributor to infertility. The most broadly accepted etiology is that uterine endometrial cells ...