Stop the Spread. Injecting saline into mouse kidneys did not affect the left or right substantia nigra (top). Injecting fibrils of α-synuclein ablated about half of the dopaminergic neurons (middle ...

[10] and the difficulty in separating symptomatic benefit from actual prevention of cell death and from the maintenance or facilitation of mechanisms that compensate for the loss of dopaminergic ...

The energy imbalance also affects subcortical regions, including the massive axonal arbors in the striatum of substantia nigra pars compacta neurons ... is vital for the proper development of ...

The pathological hallmark of PD is the abnormal aggregation of α-synuclein (α-syn) into insoluble fibrils and Lewy bodies, which causes the degeneration and death of dopaminergic neurons in the ...

This manuscript describes valuable findings regarding the expression pattern of orexin receptors in the midbrain ... tegmental area and substantia nigra promotes locomotion and reward processing, but ...

Parkinson’s disease is a progressive neurodegenerative disease that destroys substantia nigra dopaminergic neurons, causing tremors, bradykinesia, rigidity, and postural instability. Current treatment ...

A new study has identified a group of neurons that, when activated, can induce a hypometabolic state, akin to hibernation. The discovery could have far-reaching implications for conditions like ...

Their findings, published in Nature Neuroscience, show that different types of cNTS neurons process gut-originating signals via distinct sensory pathways, collectively contributing to the ...

Distinct hippocampal neurons influence food preferences and obesity risk by responding to specific nutrients and forming spatial memory of food cues. Study: Separate orexigenic hippocampal ...

Everything may die, nothing may be regenerated,” he wrote. The inability of adults to produce new neurons was pretty much the central dogma of neuroscience until the 1960s. But as with a lot of ...

Using an α-syn fibril-induced PD model, the researchers attempted to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain through use of the wireless DBS nanosystem.