Using α-syn fibril-induced PD model, researchers aimed to restore the degenerated dopaminergic neurons in the substantia nigra of the midbrain by the wireless DBS nanosystem. After stereotactic ...

A novel wireless photothermal DBS nanosystem uses nanoparticles to target and restore damaged neurons in Parkinson’s disease, ...

Seven of them also had Lewy body- and Lewy neurite-like inclusions in the spinal cord, midbrain, and amygdala ... These mice lost dopaminergic neurons in the substantia nigra and striatum, areas most ...

Its pathological hallmark is the abnormal aggregation of α-synuclein (α-syn) into insoluble fibrils and Lewy bodies, leading to the degeneration and death of dopaminergic neurons in the substantia ...

On brain parenchyma sonography, there is a marked hyperechogenicity of the substantia nigra. In PSP, there is gross midbrain atrophy ... Achromatic ballooned neurons and coiled bodies are also ...

The main pathological changes associated with PD include the loss of dopaminergic neurons in the substantia nigra/striatum and the presence of Lewy neuritis, which result in movement disorders.

This manuscript describes valuable findings on the expression pattern of orexin receptors in the midbrain and ... tegmental area and substantia nigra promotes locomotion and reward processing, but it ...