After three straight seasons of long playoff runs, the San Francisco 49ers are packing up and heading home early for a change ...

Jauan Jennings’ ejection and Isaac Guerendo’s cart-off knee injury added to the 49ers’ season-long macabre in Sunday’s 47-24 ...

The Cardinals are 1-5 since the bye week but have a chance to finish strong against the 49ers on Sunday afternoon in Glendale ...

The San Francisco 49ers fired special teams coach Brian Schneider following a season when repeated blunders in the kicking ...

Now that the NFL's regular season has ended, for most football fans, the next big event on their radar is Super Bowl 59.

John Lynch and Kyle Shanahan can go back to the drawing board and embrace an offseason of renewal and resolutions.

George Kittle disagreed with defensive end Nick Bosa's comments after following up their Super Bowl loss with another disappointing season.

The Super Bowl is closer than you think, with the NFL's biggest game coming up next month. Here's what to know ahead of Super Bowl 59.

Lions CB Emmanuel Moseley played his first five NFL seasons with the San Francisco 49ers after signing with the team as an ...

NFL Week 18 odds, picks, predictions, TV channel, streaming information for Sunday football game between San Francisco 49ers ...

The Detroit Lions' matchup against the San Francisco 49ers was essentially meaningless for the Lions, with the top seed in ...

San Francisco 49ers wide receiver Deebo Samuel walked off the field with a towel on his head, shielding him from the dreadful McDonalds-colored confetti that ra ...