With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

With both McCaffrey and Jordan Mason on injured reserve as the 49ers head down the stretch, they turned to rookie Isaac ...

Before every game Christian McCaffrey plays in, the All-Pro running back selects a young 49ers Faithful to gift an official ...

After placing RBs Jordan Mason and Christian McCaffrey on the IR, the 49ers are now promoting RB Patrick Taylor Jr. to the active roster. Considering that there’s only 5 games left in the season ...

San Francisco 49ers running back Christian McCaffrey (23) runs against Buffalo Bills safety Taylor Rapp, bottom, during the first half of an NFL football game in Orchard Park, N.Y., Sunday ...

Winters is day-to-day due to a neck issue, Lindsey Pallares of the 49ers' official site reports. Winters appears to have hurt his neck in some manner during Thursday's Week 15 loss to the Rams.

Guerendo inherited the 49ers top running back role after Christian McCaffrey and Jordan Mason both suffered injuries against the Bills in Week 13. Guerendo totaled 128 yards from scrimmage with a pair ...

Guerendo stepped up big time in Week 14 against the Bears after injuries to both Christian McCaffrey and Jordan ... becoming just the fourth player in 49ers history to total 100 yards and two ...

After Thursday night’s 12-6 win over the 49ers, Rams running back Kyren Williams told reporters in the locker room that the pilot of the team’s plane mentioned that the Rams had the chance to sweep ...

Stephania Bell: After proving he, too, could step into the starting lineup with no Christian McCaffrey (PCL ... opponents are the San Francisco 49ers (on Thursday night) and New York Jets on ...

With a passing error and a sack, the 49ers don't advance and the Los Angeles Rams win 12-6! With the clock running out at the ...