ERK substrates were identified in nearly every ... other perturbations used in the studies do not sufficiently displace PI3K from active KRAS. In addition, active KRAS may engage non-RAF effectors ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

KRAS mutation in endothelial cells activates the MEK/ERK pathway, but has no direct effect on PI3k. Subsequently, KRAS/BRAF activates the Notch pathway or TGFb/BMP pathway through the MEK/ERK ...

Phosphatidylinositol 3-kinase (PI3K): A signaling pathway involved in various cellular processes, including cell growth and migration. ERK/GSK3β/cofilin signaling pathway: A pathway that ...

More information: Toshinori Yoshioka et al, Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert ...