ERK substrates were identified in nearly every ... other perturbations used in the studies do not sufficiently displace PI3K from active KRAS. In addition, active KRAS may engage non-RAF effectors ...

Phosphatidylinositol 3-kinase (PI3K): A signaling pathway involved in various cellular processes, including cell growth and migration. ERK/GSK3β/cofilin signaling pathway: A pathway that ...

Depression continues to grapple a large proportion of the population. Given the side effects associated with the long-term use of conventional antidepressants, there is a need for novel rapid acting ...

The major signaling patways in HCC have been identified as the Ras/Raf/MEK/ERK, PI3k/Akt/mTOR and Wnt/β-catenin pathways. Different angiogenics/receptors (e.g., VEGF and PDGF) have been ...

while the anxiolytic effects were associated with activation of the amygdala through ERK signaling. Further studies in a mouse model of depression revealed that when KNT-127 was locally injected ...

The release of microvesicles is also regulated by proteins like ARF6, PLD, ERK, and MLCK, which initiate a cascade leading ... networks within the cardiovascular system, including the AMPK/PI3K/AKT ...

More information: Toshinori Yoshioka et al, Delta opioid receptor agonists activate PI3K–mTORC1 signaling in parvalbumin-positive interneurons in mouse infralimbic prefrontal cortex to exert ...

Depending on the contents of different cells and tissues, the typical signaling pathways that are downstream of FGF/FGFR interactions include the Ras/Raf-MEK-MAPK (mitogen-activated protein kinase), ...

Dual blocking SHP2 and FGFR2 can not only promote the targeted tumor-killing effects and overcome FGFR2 inhibitor resistance caused by feedback activation, but also activate T cell-mediated anti-tumor ...