RAS(ON) promotes several important signaling pathways, primarily the RAS-RAF-MEK-ERK pathway and the RAS-PI3K-AKT-mTOR pathway, thus playing an important role in cell survival and cell cycle ...

This evidence suggests that PI3K/Akt signaling is involved in the regulation of normal ... ER, estrogen receptor; ERBB4, epidermal growth factor receptor 4; ERK, extracellular signal-regulated kinase; ...

Alterations in the expression and activity of specific translation factors, and the uncoupling of translational regulation from inhibition by tumour cell stresses, such as hypoxia and nutrient ...

Aberrant activation of the Ras/Raf/MAPK/ERK kinase/extracellular signal-regulated kinase cascade and the VEGF pathway are commonly observed in breast cancer cells leading to malignant cell ...