ERK substrates were identified in nearly every ... other perturbations used in the studies do not sufficiently displace PI3K from active KRAS. In addition, active KRAS may engage non-RAF effectors ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

Phosphatidylinositol 3-kinase (PI3K): A signaling pathway involved in various cellular processes, including cell growth and migration. ERK/GSK3β/cofilin signaling pathway: A pathway that ...

The major signaling patways in HCC have been identified as the Ras/Raf/MEK/ERK, PI3k/Akt/mTOR and Wnt/β-catenin pathways. Different angiogenics/receptors (e.g., VEGF and PDGF) have been ...

The researchers treated the cells with varying concentrations of cordycepin and compared them to cells treated with known inhibitors of specific kinases in the MEK/ERK and PI3K/AKT/mTOR pathways.

Clinicaltrials.gov identifier. RAF, PI3K and the RAL guanine exchange factor (RAL-GEF) were initially identified as essential components of RAS-mediated transformation in rodent cells. Human cell ...