Palestinians will certainly resist. The nature of the resistance will prove critical in the success or failure of the Israeli scheme.

West Bank annexation could also undermine Israeli alliances with Egypt and Jordan and alienate European military partners who have assisted U.S. missile defense efforts, leaving Washington alone to shoulder the burden.

Greenfield, criticized Israel's behaviour in the West Bank at a meeting of the UN Security Council on Wednesday. Thomas-Greenfield accused Israeli settlers of carrying out extreme violence against Palestinians in the territory.

Israeli forces have detained dozens of Palestinians from various towns across the West Bank, amid military incursions into the territory.

ABC News’ Britt Clennett reports on how the second Trump presidency could impact whether Israel allows Jewish settlers to stake claims to disputed territory in the Golan Heights and the West Bank.