ascopubs.org

Prevalence of germline variants of uncertain significance in DNA repair genes and their potential impact on prostate cancer outcomes following radical prostatectomy.

Targeting highly aggressive ductal prostate tumours with poly ADP ribose polymerase inhibitor (PARPi) and androgen receptor signaling inhibitor (ARSi) combination therapy. This is an ASCO Meeting ...

Prioritizing potentially cancer-causing mutations in real-world cancer genomics

Hiroshima University researchers have developed a practical framework to identify candidate pathogenic variants hidden among the large number of variants of uncertain significance (VUS) detected in ...
MedPage Today

In Newly Diagnosed Prostate Cancer, Detecting Variants in Homologous Recombination Repair Genes

Identification of variants influences treatment decisions. Inhibitors of the poly-ADP-ribose polymerase (PARP) system, a pathway for repairing single-stranded DNA breaks, are recommended for tumors ...
Healio

Findings allow for better risk assessment and personalized treatment for BRCA2 carriers

Please provide your email address to receive an email when new articles are posted on . Researchers assigned clinical classifications to thousands of BRCA2 variants of uncertain significance. Research ...
Nasdaq

Pharming Group to host webcast on findings of a new study published in Cell advancing functional classification of variants of uncertain significance (VUS) to improve APDS ...

Leiden, the Netherlands, June 24, 2025: Pharming Group N.V. (“Pharming” or “the Company”) (EURONEXT Amsterdam: PHARM/Nasdaq: PHAR) announces it will host a webcast for investors and analysts featuring ...
Medical Xpress

Finding patterns in genetic uncertainty: Clues for inborn errors of immunity

However, it can also add a layer of complexity. Instead of simple answers, patients may be informed of gene variants of uncertain significance (VUS)—DNA changes that scientists can detect but, at this ...

RNA sequencing platform unlocks rare disease diagnoses missed by standard tests

Researchers from Children's Hospital of Philadelphia (CHOP) developed a new RNA sequencing strategy that can reveal how genetic variants disrupt gene function and improve the diagnosis of rare ...
EurekAlert!

Overview of a framework for prioritizing variants of uncertain significance (VUS) identified by comprehensive genomic profiling (CGP) (IMAGE)

Overview of a framework for prioritizing variants of uncertain significance (VUS) identified by comprehensive genomic profiling (CGP), based on real-world data from 2,172 tests showing a higher ...
ascopubs.org

Routinely Updating Patients With Cancer About Variant of Uncertain Significance Reclassifications: A Premature Responsibility for Community Oncologists

Routinely Updating Patients With Cancer About Variant of Uncertain Significance Reclassifications: A Premature Responsibility for Community Oncologists. The following represents disclosure information ...