The amount of haemoglobin in the ischaemic hemisphere was reduced by 50% in imatinib-treated mice, suggesting that imatinib may restore neuroprotection, thus extending the therapeutic window for tPA.

The company’s lead compounds exhibit high efficacies with minimal toxicities that are expected to improve therapeutic windows. Vincerx believes that partners with first-in-class antibodies ...

The latest two examples were the NXY-059 and EPO trials. [61–63] In addition, most of these trials did not recruit in later time windows, so they do not offer any perspective in terms of ...

Serina believes that by using POZ technology, drugs with narrow therapeutic windows can be designed to maintain more desirable and stable levels in the blood. Serina’s POZ platform delivery ...

SON-1010, after receipt of data suggesting clinical benefit when administered as a monotherapy in patients with advanced solid tumors, enters ...

This perspective will cover the recently completed and currently recruiting acute stroke trials with respect to their potential role in expanding the therapeutic time window for acute ischemic stroke.