All eukaryotic cells contain protein complexes called proteasomes. Proteasomes maintain the concentration of proteins in cells as well as disposing of unneeded or damage proteins. The process of ...
he ubiquitin‒proteasome system (UPS) and autophagy are protein degradation pathways essential for maintaining protein balance and regulation, or proteostasis (left panel). When proteasome activity ...
The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation of ubiquitylated proteins. As the maintenance of protein homeostasis is essential to ...
For more than two decades, medical providers have treated multiple myeloma (MM) with proteasome inhibitors (PIs). This important drug therapy has helped improve survival rates of people with MM.
Focal bone marrow processes and early bone lesions in patients with multiple myeloma (MM) precursor diseases: A prospective study using molecular imaging. This is an ASCO Meeting Abstract from the ...
Although they are not alive themselves, proteins nonetheless progress through a life cycle of sorts: they are created by the cell, serve a specific purpose in the organism, and ultimately expire ...
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Experimental model enables study of how protein complex influences mitochondrial function
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
Researchers from Harvard Medical School (HMS) have discovered how a protein called midnolin plays a key role in degrading many short-lived nuclear proteins. Their study showed that midnolin acts by ...
A study by the Center for Redox Processes in Biomedicine (Redoxoma) led by Marilene Demasi from the Butantan Institute (São Paulo, Brazil) presents a valuable new experimental model for investigating ...
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