The mechanism of action of mesalamine is not fully understood, but appears to be a topical anti-inflammatory effect on colonic epithelial cells. Mucosal production of arachidonic acid metabolites ...

Medically reviewed by Jay N. Yepuri, MD An enema is a process in which fluids are injected into your rectum to cleanse your large intestine (colon), stimulate a bowel movement, or deliver medication.