This may also result in significant adverse effects, including electrolyte imbalance, ototoxicity, and volume contraction. Prolonged use of loop diuretics may lead to loop diuretic resistance ...

[23] Electrolyte imbalance ... or hepatic disease. Adverse effects are listed in Table II. In summary, loop diuretics are the mainstay of diuretic therapy in CHF. One must consider the physiologic ...

Intravenous diuretic therapy is the current standard of care for hypervolemic heart failure, but loop diuretics ... owing to adverse effects on neurohormonal activation, electrolyte balance ...