ERK substrates were identified in nearly every ... other perturbations used in the studies do not sufficiently displace PI3K from active KRAS. In addition, active KRAS may engage non-RAF effectors ...

A groundbreaking review highlights significant advancements in the understanding and treatment of cerebral vascular malformations (CVMs), emphasizing the potential of precision medicine. Integrating ...

The major signaling patways in HCC have been identified as the Ras/Raf/MEK/ERK, PI3k/Akt/mTOR and Wnt/β-catenin pathways. Different angiogenics/receptors (e.g., VEGF and PDGF) have been ...

The laboratory is studying small molecules that selectively inhibit the components of RAS-RAF-MEK-ERK and PI3K-AKT-mTOR pathways. These compounds are being used as reagents to define the role of these ...

One particular compound demonstrated significant anti-inflammatory activity by suppressing the PI3K/AKT/MEK/ERK signaling pathway, which is often activated in inflammatory responses[3].

The global burden of anxiety- and depression-related disorders is on the rise. While multiple drugs have been developed to treat these conditions, current medications have several limitations, ...

The researchers treated the cells with varying concentrations of cordycepin and compared them to cells treated with known inhibitors of specific kinases in the MEK/ERK and PI3K/AKT/mTOR pathways.

Clinicaltrials.gov identifier. RAF, PI3K and the RAL guanine exchange factor (RAL-GEF) were initially identified as essential components of RAS-mediated transformation in rodent cells. Human cell ...