Subtle signs of neurodegeneration can be detected in blood, CSF, and neuroimaging, up to 20 years before the motor symptoms ...

Opens in a new tab or window Cerebrospinal fluid analysis revealed elevated neurofilament light protein and proenkephalin levels 23 years before clinical diagnosis of Huntington's disease.

For the new study, the researchers studied 57 people with the Huntington's disease gene expansion, who were calculated as being on average 23.2 years from a predicted clinical motor diagnosis ...

About 2,000 people in Australia are affected by Huntington's disease, a fatal and incurable condition that affects the nervous system that results in the death of brain cells.

New genetic research shows why some people develop deadly Huntington's disease earlier than others. The findings could lead to better treatments.

A study published in Nature Medicine reveals subtle neurodegenerative changes in people with Huntington’s disease gene expansion up to 20 years before symptoms appear. Using advanced imaging, blood ...

Symptoms of Huntington's disease appear late in life. Research reveals how DNA repeats grow toxic over time, explaining the ...

Beta blockers were associated with later appearance of motor symptoms and slower symptom worsening, but an outside expert ...

The cumulative death of many such cells leads to the symptoms of Huntington's disease. The study offers a potential explanation as to why candidate Huntington's drugs that aim to reduce expression ...

A recent study published in Cell reveals that the repeated DNA sequence that leads to Huntington’s disease (HD) expands ...

Get Instant Summarized Text (Gist) Subtle brain changes in individuals with the Huntington's disease gene occur up to 20 years before clinical symptoms appear. Advanced imaging and biomarker ...

Somatic CAG repeat expansion in blood associates with biomarkers of neurodegeneration in Huntington’s disease decades before clinical motor diagnosis. Nature Medicine , 2025; DOI: 10.1038/s41591 ...