Live Science on MSN5d
1st-of-its-kind database reveals how DNA mutations 'destabilize' proteins, triggering genetic disease
A new mega-database of half a million mutations may flag new ways of treating genetic disease, scientists say.
Medical Xpress on MSN8d
Human ‘domainome’ reveals root cause of heritable disease
They found that 72% (13 out of 18) of mutations linked to cataract formation destabilise crystallin proteins, making the ...
Medscape2mon
alphaB-crystallin Is a Marker of Aggressive Breast Cancer Behavior but Does Not Independently Predict for Patient Outcome
The MS110 antibody from Merck KGaA (Darmstadt, Germany) was used for BRCA1 detection (1:150 dilution, for 20 min), while p53 protein was ... alphaB-crystallin (strong positive, weak positive ...
GEN7d
“Human Domainome” Reveals Cause of Many Diseases
Researchers eventually want to map the effects of every possible mutation on all human proteins to transform precision ...