Dr. Smith earned his MD at Case Western Reserve University in Cleveland, Ohio (Phi Beta Kappa), going on to a general surgery internship and residency and a vascular surgery fellowship at the University of Rochester Medical Center/Strong Memorial Hospital (1977-1982). He completed his cardiothoracic surgery residency at Columbia-Presbyterian Medical Center in 1984, immediately joining the faculty of the Columbia University College of Physicians and Surgeons. He was Director of Cardiopulmonary Transplantation at Columbia-Presbyterian Medical Center during 1986-1996 and was appointed Chief of the Division of Cardiothoracic Surgery in 1996. He became a full professor of surgery in 1998. In 2010, Dr. Smith became Chair, Department of Surgery. Dr. Smith's clinical specialties include medical support for pre- and postoperative transplant recipients, use of bioartificial support devices, and alternative immunosuppressive strategies.